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Leiomyosarcoma of the larynx is very rare, and rarely been described in reference to the head and neck region. This tumor occurs mainly in the uterus, the gastrointestinal track, and the retroperitoneum. There have been 24 previously reported cases of this tumor involving the larynx in the literature. Histologic diagnosis remains extremely difficult. A case of leiomyosarcoma of the larynx, treated by total laryngectomy, is reported. We discuss the clinical presentation, diagnosis, and treatment of leiomyosarcoma with a review of the literature.
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